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Vitamin B6, or pyridoxine, is a water-soluble vitamin found naturally in many foods, as well as added to foods and supplements. Pyridoxal 5' phosphate (PLP) is the active form of the coenzyme and the most common measurement of blood B6 levels in the body. PLP is a coenzyme that helps more than 100 enzymes perform various functions, including breaking down proteins, carbohydrates, and fats, maintaining normal homocysteine levels (as high levels can cause heart problems), and supporting immune function and health of the brain.